Histadelia/Undermethylation

Histadelia, also known as undermethylation, can cause depression, obsession or compulsive perfectionism. Histadelia causes an excess of histamine in the body. Histamine is involved in many reactions in the brain, including stimulating the release of the neurotransmitters serotonin, dopamine and norepinephrine. High levels of histamine can have a serious effect on mood and mental health.

Symptoms of Histadelia/Undermethylation

Symptoms can include:

  • depression
  • obsessive-compulsive tendencies, perfectionism or feeling driven
  • high motivation
  • racing brain
  • agressiveness
  • inner tension
  • oppositional defiant disorder in children
  • insomnia, not needing much sleep
  • headaches
  • respiratory allergies
  • high libido
  • high sensitivity to pain
  • large ears, hands or feet or long fingers or toes
  • addiction to drugs, alcohol or sugar

Take the histadelia test to find out if you could have histadelia. Or, take our 13 depression tests to find out if you could have one of 13 common causes of depression.

People with high histamine often don't appear to be depressed. With driven, type A personalities and high levels of energy and motivation, they can be very successful in their careers. However they suffer from constant inner tension, an inability to switch off and chronic depression that can be severe and even suicidal. They often turn to drugs or alcohol to help them cope as these substances temporarily lift the depression by reducing histamine in the body.

A range of physical symptoms are involved. Histamine increases the metabolic rate and people with high histamine usually burn up food quickly and stay thin. A high metabolic rate increases the body temperature and people with high histamine often develop large ears, hands or feet, long fingers and toes and have little body or facial hair to help dissipate the extra heat.

Histamine stimulates the production of body fluids so histadelics usually have plenty of saliva and produce tears easily. Tooth decay is rarely a problem because high saliva levels help protect the teeth against decay.

Headaches, respiratory allergies and a high sensitivity to pain are common.

Diagnosis of Histadelia/Undermethylation

If you think you may have histadelia, a doctor or health care provider can order a blood test to check your histamine levels. You should also ask for a test for the MTHFR gene. A mutation in this gene leads to an inability to convert folic acid to the form of folate needed by the body and this is one cause of histadelia.

However the research on histadelia is relatively new and many doctors are unfamiliar with the condition. See Finding a doctor who knows about histadelia.

Treatment of Histadelia/Undermethylation

There are a number of different treatment protocols for histadelia. The high histamine levels are caused by a problem the methylation cycle, a complex sequence of chemical reactions in the body, and the supplements you need will depend on where in this sequence you have a problem.

People with a mutation in the MTHFR gene need to take 5-MTHF (5-Methyl Tetrahydrofolate), the form of folate that is used by the body, together with methylcobalamin, the form of B12 that is used by the body. It is important that these people avoid regular folic acid, as they are unable to process it and it can make symptoms worse. In particular, most B-complexes and multivitamins contain regular folic acid, so if you take one of these, choose one like Thorne Research B Complex or Thorne Research Multivitamin that only has 5-MTFH and calcium folinate, the two forms of folate that are used by the body.

People who don't have the MTHFR gene mutation are usually given a combination of supplements that support the methylation process. Most practitioners use either SAMe or methionine (SAMe is usually faster acting and more effective but can cause stomach aches for some people) together with calcium and magnesium, Vitamin C and B6. 5-HTP is often used short term to boost the mood and inositol can be very helpful for obsessive behaviour.

Depression-Free, Naturally: 7 Weeks to Eliminating Anxiety, Despair, Fatigue, and Anger from Your Life  has a full treatment protocol for people who DON'T have the MTFHR gene mutation, including dosages.

High protein diets should be avoided as most protein contains histadine, an amino acid used by the body to produce histamine. Folic acid and high levels of vitamin B3 or B5 should be avoided as they can increase histamine levels.

Most people will see an improvement within a week, though it may take a year for symptoms to stabilize completely and treatment must be continued for life.

Other Causes of Depression

Take our 13 depression tests to find out if you could have any of the other common causes of depression.




Where to Find More Information

Depression Free NaturallyDepression-Free, Naturally: 7 Weeks to Eliminating Anxiety, Despair, Fatigue, and Anger from Your Life This is one of our top 3 books on depression. It covers a wide range of conditions, including a well written section on histadelia. The author has run a highly successful clinic dealing with histadelia and other biochemical causes of depression for over 30 years.


Finding a doctor who knows about histadelia