Histapenia/Overmethylation (Low Histamine Levels)

Histapenia, also known as overmethylation, causes low levels of histamine in the body, leading to depression, paranoia and irritability. Histamine is involved in many reactions in the brain, including stimulating the release of the neurotransmitters serotonin, dopamine and norepinephrine. Low levels of histamine can have a serious effect on mood and mental health.

Histapenia/Overmethylation Symptoms

Symptoms can include:

  • depression with despair and bouts of crying
  • paranoia or suspicion
  • racing thoughts
  • grandiose ideas
  • irritability
  • fatigue
  • pear shaped body
  • lots of dental fillings
  • low libido
  • high tolerance for pain
  • food allergies

Take the histapenia test to find out if you could have histapenia. Or, take our 13 depression tests to find out if you could have one of 13 common causes of depression.

Diagnosis

A doctor or health care provider can order a blood test to check your histamine levels. However the research on histapenia is relatively new and many doctors are unfamiliar with the condition. See Finding a doctor who knows about histapenia.

Treatment

Treatment involves taking a range of supplements that interact to raise histamine levels in the body, and may include folic acid, B12, niacinamide, zinc, manganese, GLA (from evening primrose oil), Omega-3 fatty acids (from fish oil), vitamin C, DMAE, choline, and histidine.

Depression-Free, Naturally: 7 Weeks to Eliminating Anxiety, Despair, Fatigue, and Anger from Your Life  has a full treatment protocol including dosages.

Some supplements commonly used in the treatment of depression should be avoided as they can lower histamine levels and make symptoms worse - these include methionine, SAMe, inositol, phenylalanine, St. John’s wort, tyrosine, copper, TMG and DMG.

Most people will see an improvement within a week, though it may a year for symptoms to stabilize completely and treatment must be continued for life.

Other Causes of Depression

Take our 13 depression tests to find out if you could have any of the other common causes of depression.




Where to Find More Information

Depression Free NaturallyDepression-Free, Naturally: 7 Weeks to Eliminating Anxiety, Despair, Fatigue, and Anger from Your Life
This is one of our top 3 books on depression. It covers a wide range of conditions, including a well written section on histapenia. The author has run a highly successful clinic dealing with histapenia and other biochemical causes of depression for over 30 years.