Acetylcholine Deficiency - How to Increase Acetylcholine

Acetylcholine is an important brain chemical for clear thinking, memory, motivation and concentration.

Acetylcholine Deficiency Symptoms

Symptoms of low acetylcholine levels can include:

  • poor focus and concentration
  • memory problems - difficulty remembering names and faces, birthdays, lists, directions or instructions
  • misplacing your keys, wallet or glasses frequently
  • slow and/or confused thinking
  • difficulty finding the right words
  • disorientation
  • making simple mistakes at work
  • introversion - preferring to do things alone rather than in groups
  • feeling of despair, lack of joy

Take the acetylcholine deficiency test to find out if you could be low in acetylcholine. Or, take our 13 depression tests to find out if you could have one of 13 common causes of depression.

Acetylcholine is made in the body from choline, a B vitamin found in foods like eggs, liver and beef.

What Causes Low Acetylcholine Levels?

Acetylcholine levels can be low for a number of reasons, including:

  • not enough B vitamins in the diet - Acetylcholine is made from the B vitamin choline, with the assistance of vitamins B1 and B5.
  • too much sugar - a high sugar intake robs the body of its vitamin B stores, reducing acetylcholine production.
  • too much stress - stress uses up B vitamins and depletes acetylcholine levels in the body.
  • exposure to mercury, lead, aluminium, PCB’s, fertilizers, pesticides or EMF can all interfere with acetylcholine production in the body.


Blood tests and urine tests can be used to measure your amino acid levels, but many physicians are not familiar with their use. Some practitioners say the tests are unreliable and a questionnaire will give a better indication of amino acid levels. If you want to get the testing done, try Googling 'Amino Acid Testing', contact one of the labs that does the testing and ask them to suggest a practitioner in your area who is familiar with the tests. If you can't find a practitioner, some labs let you order the test yourself online.

How to Increase Acetylcholine Naturally

Choline suppplements can rapdily increase acetylcholine levels and improve memory and concentration. GPC Choline (L-alpha-glycerylphosphorylcholine) is one of the best forms of choline to take as it is easily absorbed by the body.

Phosphatidylserine is an essential fatty acid that helps build brain cell membranes that are fluid enough to release the neurotransmitters acetylcholine and dopamine. Life Extension's Cognitex Basics contains both GPC choline and phosphatidylserine.

A good quality B complex will provide the B1 and B5 that are needed to assist with acetylcholine production.

Other Causes of Depression

Take our 13 depression tests to find out if you could have any of the other common causes of depression.

Where to Find More Information

The Ultramind Solution - The Simple Way to Defeat DepressionThe UltraMind Solution: The Simple Way to Defeat Depression, Overcome Anxiety, and Sharpen Your Mind This book has a comprehensive chapter on neurotransmitter and amino acid deficiencies, including information on acetylcholine deficiency and how to increase acetylcholine naturally. Also includes information on how to heal your brain by optimizing nutrition, balancing your hormones, reducing inflammation, fixing your digestion, detoxifying and boosting your energy metabolism.